Sodium Glycinate → HCID 54751139, compound

HRID 1511926Notes

Reaction equation

HRID 1511926 reaction equation
C(O[C:4]([C:6]1[C:11](=[O:12])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[N:9]2[CH:22]=[CH:23][CH:24]=[C:8]2[C:7]=1[OH:25])=[O:5])C.[NH2:26][CH2:27][C:28]([O-:30])=[O:29].[Na+]>>[F:21][C:15]1[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=1[CH2:13][N:10]1[C:11](=[O:12])[C:6]([C:4]([NH:26][CH2:27][C:28]([OH:30])=[O:29])=[O:5])=[C:7]([OH:25])[C:8]2=[CH:24][CH:23]=[CH:22][N:9]12

Participants

3

Reactant 2

HCID 4684308Sodium GlycinateHCID 67231559HCID 67231559, compound

Product 1

HCID 54751139HCID 54751139, compound

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 1-(2,4-difluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 378 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a893257b55734f68b03234be00091db3
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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