Sodium Glycinate → HCID 54751142, compound

HRID 1511935Notes

Reaction equation

C(O[C:4]([C:6]1[C:11](=[O:12])[N:10]([CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[N:9]2[CH:24]=[CH:25][CH:26]=[C:8]2[C:7]=1[OH:27])=[O:5])C.[NH2:28][CH2:29][C:30]([O-:32])=[O:31].[Na+]>>[OH:27][C:7]1[C:8]2[N:9]([CH:24]=[CH:25][CH:26]=2)[N:10]([CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[C:11](=[O:12])[C:6]=1[C:4]([NH:28][CH2:29][C:30]([OH:32])=[O:31])=[O:5]

Participants

Reactant 2

HCID 4684308Sodium Glycinate

HCID 67231338HCID 67231338, compound

Product 1

HCID 54751142HCID 54751142, compound

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 4-hydroxy-1-naphthalen-2-ylmethyl-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 392 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-2ab1427e9f334dd8a10282c94c241042
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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