Sodium Glycinate → {[1-(4-Chloro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid

HRID 1511941Notes

Reaction equation

HRID 1511941 reaction equation
C(O[C:4]([C:6]1[C:11](=[O:12])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:9]2[CH:21]=[CH:22][CH:23]=[C:8]2[C:7]=1[OH:24])=[O:5])C.[NH2:25][CH2:26][C:27]([O-:29])=[O:28].[Na+]>>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]2[C:11](=[O:12])[C:6]([C:4]([NH:25][CH2:26][C:27]([OH:29])=[O:28])=[O:5])=[C:7]([OH:24])[C:8]3=[CH:23][CH:22]=[CH:21][N:9]23)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 4684308Sodium GlycinateHCID 672308401-(4-Chloro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

Product 1

HCID 54751144{[1-(4-Chloro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 1-(4-chloro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 376 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-590d6b6bb3af4c4f8e9ebff41f33aaff
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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