Sodium hydride → HCID 67230419, compound

HRID 1511942Notes

Reaction equation

HRID 1511942 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Cl)=[CH:18][CH:17]=1.[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:20][C:19]1[CH:22]=[CH:23][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 699934-Methyloxybenzyl chlorideHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

Product 1

HCID 67230419HCID 67230419, compound

Procedure

Prepared according to the benzylation condition used in Example 1 step b) from pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 4-methoxybenzyl chloride (1.03 eq.) and sodium hydride (1.3 eq.). ESI (m/z): 303 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-217aecb29ef04ec69c5e7887723adc0f
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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