Sodium hydride → (2,6-Difluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

HRID 1511951Notes

Reaction equation

HRID 1511951 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[F:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:16]=1[CH2:17]Cl.[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:17][C:16]1[C:15]([F:14])=[CH:22][CH:21]=[CH:20][C:19]=1[F:23])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 5815702,6-Difluorobenzyl chlorideHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

Product 1

HCID 67230234(2,6-Difluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

Procedure

Prepared according to the benzylation condition used in Example 1 step b) from pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 2,6-difluorobenzyl chloride (1.0 eq.) and sodium hydride (1.3 eq.). ESI (m/z): 309 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2ff6673243d1415e9066526f50ebf530
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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