HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl methanetricarboxylate → 1-(2,6-Difluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl methanetricarboxylate | HCID 80471 | — |
| Reactant | (2,6-Difluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester | HCID 67230234 | — |
| Product | 1-(2,6-Difluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester | HCID 67230758 | — |
Reaction Steps
Prepared according to the thermal cyclization condition used in Example 1 step c) from (2,6-difluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (3.0 eq.). ESI (m/z): 349 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217043B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-fff339a69d764107b5acf61700d6acd3 |
| Source note | uspto-grants-2012_07 |