Sodium hydride → (2-Trifluoromethyl-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

HRID 1511954Notes

Reaction equation

HRID 1511954 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[F:14][C:15]([F:25])([F:24])[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Cl.[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:18][C:17]1[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=1[C:15]([F:14])([F:24])[F:25])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 890281-(Chloromethyl)-2-(trifluoromethyl)benzeneHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

Product 1

HCID 67229934(2-Trifluoromethyl-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

Procedure

Prepared according to the benzylation condition used in Example 1 step b) from pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 2-trifluoromethylbenzyl chloride (1.0 eq.) and sodium hydride (1.3 eq.). ESI (m/z): 341 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-efb395964d2b48c69360c607e27b29af
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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