Sodium Glycinate → [(1-Butyl-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl)-amino]-acetic acid

HRID 1511960Notes

Reaction equation

C(O[C:4]([C:6]1[C:11](=[O:12])[N:10]([CH2:13][CH2:14][CH2:15][CH3:16])[N:9]2[CH:17]=[CH:18][CH:19]=[C:8]2[C:7]=1[OH:20])=[O:5])C.[NH2:21][CH2:22][C:23]([O-:25])=[O:24].[Na+]>>[CH2:13]([N:10]1[C:11](=[O:12])[C:6]([C:4]([NH:21][CH2:22][C:23]([OH:25])=[O:24])=[O:5])=[C:7]([OH:20])[C:8]2=[CH:19][CH:18]=[CH:17][N:9]12)[CH2:14][CH2:15][CH3:16]

Participants

Reactant 2

HCID 4684308Sodium Glycinate

HCID 672309931-Butyl-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

Product 1

HCID 54751149[(1-Butyl-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl)-amino]-acetic acid

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 1-butyl-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 308 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-c063337afecc42f18768294a65ef407e
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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