Sodium Glycinate → HCID 54751150, compound

HRID 1511963Notes

Reaction equation

HRID 1511963 reaction equation
CO[C:3]([C:5]1[C:17](=[O:18])[N:16]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[N:15]2[C:7](=[CH:8][C:9]3[C:14]2=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:6]=1[OH:27])=[O:4].[NH2:28][CH2:29][C:30]([O-:32])=[O:31].[Na+]>>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][N:16]2[N:15]3[C:7](=[CH:8][C:9]4[C:14]3=[CH:13][CH:12]=[CH:11][CH:10]=4)[C:6]([OH:27])=[C:5]([C:3]([NH:28][CH2:29][C:30]([OH:32])=[O:31])=[O:4])[C:17]2=[O:18])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 4684308Sodium GlycinateHCID 68761498HCID 68761498, compound

Product 1

HCID 54751150HCID 54751150, compound

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 4-(4-fluoro-benzyl)-1-hydroxy-3-oxo-3,4-dihydro-4,4a-diaza-fluorene-2-carboxylic acid methyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 410 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d8f4b5a34b874817858cbf4944ba065b
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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