1-Iodohexane → HCID 67230378, compound

HRID 1511965Notes

Reaction equation

HRID 1511965 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].I[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 125271-IodohexaneHCID 24758Sodium hydrideHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

Product 1

HCID 67230378HCID 67230378, compound

Procedure

Prepared according to the N-alkylation condition used in Example 17 step a) from starting materials pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 1-iodohexane (3.0 eq.) and sodium hydride (1.3 eq.). 1H NMR (CDCl3, δ in ppm): 6.60 (m, 2H), 6.10 (m, 2H), 3.63 (t, 2H, J=7.2 Hz), 1.42 (s, 9H), 1.9-1.2 (m, 8H), 0.90 (m, 3H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-47cd9c539088479db254da3606c164c5
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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