Methyl malonyl chloride → HCID 67231001, compound

HRID 1511968Notes

Reaction equation

HRID 1511968 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH3:25][O:26][C:27](=[O:32])[CH2:28][C:29](Cl)=[O:30]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([N:16]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=2)[C:29](=[O:30])[CH2:28][C:27]([O:26][CH3:25])=[O:32])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 67230494HCID 67230494, compound

Product 1

HCID 67231001HCID 67231001, compound

Procedure

Prepared according to the acylation condition used in Example 2 step f) from 5-fluoro-1-(4-fluoro-benzylamino)-1H-indole-2-carboxylic acid ethyl ester and chlorocarbonyl-acetic acid methyl ester (1.2 eq.). 1H NMR (CDCl3, δ in ppm): 7.3-6.77 (m, 8H), 4.82 (dd, 2H), 4.17 (m, 2H), 3.54 (s, 3H), 3.26 (s, 2H), 1.31 (t, 3H, J=7.1 Hz).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e3b5460f3a4d46939b7f523f1ab094b5
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

Loading…