Sodium Glycinate → HCID 54751152, compound

HRID 1511969Notes

Reaction equation

CO[C:3]([C:5]1[C:17](=[O:18])[N:16]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[N:15]2[C:7](=[CH:8][C:9]3[C:14]2=[CH:13][CH:12]=[C:11]([F:27])[CH:10]=3)[C:6]=1[OH:28])=[O:4].[NH2:29][CH2:30][C:31]([O-:33])=[O:32].[Na+]>>[F:27][C:11]1[CH:10]=[C:9]2[C:14]([N:15]3[C:7](=[CH:8]2)[C:6]([OH:28])=[C:5]([C:3]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:4])[C:17](=[O:18])[N:16]3[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 4684308Sodium Glycinate

HCID 67229964HCID 67229964, compound

Product 1

HCID 54751152HCID 54751152, compound

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 7-fluoro-4-(4-fluoro-benzyl)-1-hydroxy-3-oxo-3,4-dihydro-4,4a-diaza-fluorene-2-carboxylic acid methyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 428 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-181c543ad81c4101adbeb9a38faa9a7e
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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