4-Chlorobenzaldehyde → HCID 67230863, compound

HRID 1511979Notes

Reaction equation

HRID 1511979 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH2:11])[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]=[CH:17][C:16]2[CH:19]=[CH:20][C:13]([Cl:12])=[CH:14][CH:15]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 22180068HCID 22180068, compound

Product 1

HCID 67230863HCID 67230863, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester and 4-chloro benzaldehyde in refluxing methanol for 12 h. 1H NMR (CDCl3, δ in ppm): 8.35 (s, 1H), 7.78 (d, 2H, J=7.6 Hz), 7.42 (d, 2H, J=7.6 Hz), 7.19 (d, 1H, J=2.2 Hz), 6.89 (d, 1H, J=2.2 Hz), 3.83 (s, 3H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f1b527f0d3a242e3bb07b37f5cb249d4
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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