4-Methoxybenzaldehyde → HCID 67230886, compound

HRID 1511983Notes

Reaction equation

HRID 1511983 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH2:11])[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]=[CH:18][C:17]2[CH:20]=[CH:21][C:14]([O:13][CH3:12])=[CH:15][CH:16]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 22180068HCID 22180068, compound

Product 1

HCID 67230886HCID 67230886, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester and 4-methoxy benzaldehyde in refluxing methanol for 12 h. 1H NMR (CDCl3, δ in ppm): 8.33 (s, 1H), 7.78 (d, 2H, J=8.8 Hz), 7.13 (d, 1H, J=2.2 Hz), 6.96 (d, 2H, J=8.8 Hz), 6.87 (d, 1H, J=1.8 Hz), 3.87 (s, 3H), 3.82 (s, 3H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f4377bfc5cb94ebd94ec008bd4f71175
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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