(1,1'-Biphenyl)-4-carboxaldehyde → HCID 67230591, compound

HRID 1511987Notes

Reaction equation

HRID 1511987 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH2:11])[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[C:12]1([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]=[CH:22][C:21]2[CH:24]=[CH:25][C:18]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[CH:19][CH:20]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 76689(1,1'-Biphenyl)-4-carboxaldehydeHCID 22180068HCID 22180068, compound

Product 1

HCID 67230591HCID 67230591, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester and 4-phenyl benzaldehyde in refluxing methanol for 12 h. 1H NMR (CDCl3, δ in ppm): 8.43 (s, 1H), 7.91 (d, 2H, J=8.4 Hz), 7.68 (d, 2H, J=8.4 Hz), 7.66-7.16 (m, 5H), 7.20 (d, 1H, J=2.2 Hz), 6.90 (d, 1H, J=1.8 Hz), 3.84 (s, 3H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-91cc82ef65d54b37a500e58c6a60996f
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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