Sodium Glycinate → HCID 54751167, compound

HRID 1511994Notes

Reaction equation

CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:8]2[CH:23]=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:25]=[C:7]2[C:6]=1[OH:32])=[O:4].[NH2:33][CH2:34][C:35]([O-:37])=[O:36].[Na+]>>[OH:32][C:6]1[C:7]2[N:8]([CH:23]=[C:24]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:25]=2)[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:20])[F:22])=[CH:15][CH:14]=2)[C:10](=[O:11])[C:5]=1[C:3]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:4]

Participants

Reactant 2

HCID 4684308Sodium Glycinate

HCID 67231791HCID 67231791, compound

Product 1

HCID 54751167HCID 54751167, compound

Procedure

Prepared according to the glycinolysis condition used in Example 1 step d) from 4-hydroxy-2-oxo-6-phenyl-1-(4-trifluoromethyl-benzyl)-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester (1.0 eq.) and sodium glycinate (5 eq.). ESI (m/z): 486 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-5f6db627c12747d69b7f98431b1a4a92
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

Loading…