3-Pyridinecarboxaldehyde → HCID 67230852, compound

HRID 1511995Notes

Reaction equation

HRID 1511995 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH2:11])[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=O)[CH:13]=1>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]=[CH:18][C:14]2[CH:13]=[N:12][CH:17]=[CH:16][CH:15]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 22180068HCID 22180068, compound

Product 1

HCID 67230852HCID 67230852, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester and pyridine-3-carbaldehyde in refluxing methanol for 12 h. 1H NMR (CDCl3, δ in ppm): 8.43 (s, 1H), 8.29-8.13 (m, 2H), 7.51-7.43 (m, 2H), 7.23 (d, 1H, J=1.8 Hz), 6.91 (d, 1H, J=1.8 Hz), 3.84 (s, 3H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f247fc892272407f93d70c411c702d0c
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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