反应详情

Prepared according to the acylation condition used in Example 2 step f) from 4-chloro-1-[(pyridin-2-ylmethyl)-amino]-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). 1H NMR (CDCl3, δ in ppm): 8.5 (m, 1H), 7.68 (m, 1H), 7.39 (m, 1H), 721 (m, 1H), 6.85 (d, 1H, J=1.6 Hz), 6.80 (d, 1H, J=1.6 Hz), 5.48 (d, 1H, J=15.4 Hz), 4.46 (d, 1H, J=15.4 Hz), 3.79 (s, 3H), 3.69 (s, 3H), 3.19 (s, 2H).

1. customPrepared