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Methyl malonyl chloride → 4-Chloro-1-[(2-methoxycarbonyl-acetyl)-pyridin-2-ylmethyl-amino]-1H-pyrrole-2-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl malonyl chloride | HCID 123460 | — |
| 反応物 | 4-chloro-1-[(pyridin-2-ylmethyl)-amino]-1H-pyrrole-2-carboxylic acid methyl ester | HCID 67229862 | — |
| 生成物 | 4-Chloro-1-[(2-methoxycarbonyl-acetyl)-pyridin-2-ylmethyl-amino]-1H-pyrrole-2-carboxylic acid methyl ester | HCID 67230577 | — |
反応手順
Prepared according to the acylation condition used in Example 2 step f) from 4-chloro-1-[(pyridin-2-ylmethyl)-amino]-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). 1H NMR (CDCl3, δ in ppm): 8.5 (m, 1H), 7.68 (m, 1H), 7.39 (m, 1H), 721 (m, 1H), 6.85 (d, 1H, J=1.6 Hz), 6.80 (d, 1H, J=1.6 Hz), 5.48 (d, 1H, J=15.4 Hz), 4.46 (d, 1H, J=15.4 Hz), 3.79 (s, 3H), 3.69 (s, 3H), 3.19 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08217043B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-eb8baeb8c11143749985cb156c646f0f |
| 出典メモ | uspto-grants-2012_07 |