Methyl malonyl chloride → HCID 67230931, compound

HRID 1512004Notes

Reaction equation

HRID 1512004 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[C:7]([Cl:11])=[C:8]([Cl:10])[CH:9]=1)=[O:4].[CH3:21][O:22][C:23](=[O:28])[CH2:24][C:25](Cl)=[O:26]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[C:25](=[O:26])[CH2:24][C:23]([O:22][CH3:21])=[O:28])[C:7]([Cl:11])=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 67231388HCID 67231388, compound

Product 1

HCID 67230931HCID 67230931, compound

Procedure

Prepared according to the acylation condition used in Example 2 step f) from 4,5-dichloro-1-(4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). 1H NMR (CDCl3, δ in ppm): 7.1-6.8 (m, 5H), 4.88 (d, 1H, J=14.6 Hz), 4.75 (d, 1H, J=14.0 Hz), 3.72 (s, 3H), 3.67 (s, 3H), 3.17 (dd, 2H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1469bbd389654343a5961eefca39bac4
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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