HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzaldehyde → HCID 66879143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzaldehyde | HCID 11477 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-5-fluoroindolin-2-one | HCID 9794083 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66879143 | HCID 66879143 | — |
Reaction Steps
In a manner similar to the method described in Example 1, 6-chloro-5-fluoro-1,3-dihydro-indol-2-one (0.25 g, 1.35 mmol) (CGENETECH) was reacted with 3-chloro-benzaldehyde (0.34 g, 2.44 mmol) and pyrrolidine (0.19 g, 2.68 mmol) in methanol to give a mixture of E- and Z-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217051B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-82f0e33931dc4a2bad30b34339a0312f |
| Source note | uspto-grants-2012_07 |