反应详情

To the HCl salt of 3-methoxy-phenylamine (4.6 g, 28.9 mmol) in 1N HCl (300 mL) was added a solution of 2-nitro-malonaldehyde (2.7 g, 19.3 mmol) in 150 mL water. After 30 min, the precipitate was filtered and rinsed with 0.1 N HCl. Air-drying in a Büchner funnel for 18 h gave 3.36 g (78%) of a light yellow/green powder. LC/MS (m/z): 245.1 (MH++Na), Rt 2.21 minutes.

1. filtrationthe precipitate was filtered
2. washrinsed with 0.1 N HCl
3. customAir-drying in a Büchner funnel for 18 h