Hydrochloric Acid → HCID 178478969, compound

HRID 1512158Notes

Reaction equation

HRID 1512158 reaction equation
[CH:1]1([CH:7]=[CH:8][C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[O:24][C:25]([F:28])([F:27])[F:26])=[CH:17][C:11]=3[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:29]>C(OCC)C>[ClH:29].[CH:1]1([CH:7]=[CH:8][C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[O:24][C:25]([F:27])([F:28])[F:26])=[CH:17][C:11]=3[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178506367HCID 178506367, compound

Product 1

HCID 178478969HCID 178478969, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 2-(2-cyclohexyl-vinyl)-5-(2-trifluoromethoxy-phenyl)-1H-benzimidazole (0.3 g, 0.78 mmol, prepared as in STEP C above) in ethyl ether (5 mL) was treated with 2M HCl in ethyl ether (0.8 mmol, 0.4 mL). After five minutes the resulting solution was concentrated and dried in vacuo to yield the title compound.

Workup

  1. concentrationAfter five minutes the resulting solution was concentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-e4a91183643345bc9e0999a8f354ffb9
Source dataset
uspto-grants-2012_07
Patent number
US08217060B2

Reaction notes

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