3-Nitro-2'-trifluoromethyl-biphenyl-4-ylamine → (E)-2-[2-(4-Methyl-tetrahydro-pyran-4-yl)-vinyl]-5-(2-trifluoromethyl-phenyl)-1H-benzimidazole

HRID 1512178Notes

Reaction equation

HRID 1512178 reaction equation
[CH3:1][C:2]1([CH:8]=[CH:9][C:10](O)=O)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[N+:13]([C:16]1[CH:17]=[C:18]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([F:32])([F:31])[F:30])[CH:19]=[CH:20][C:21]=1[NH2:22])([O-])=O>>[CH3:1][C:2]1(/[CH:8]=[CH:9]/[C:10]2[NH:22][C:21]3[CH:20]=[CH:19][C:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:30])([F:31])[F:32])=[CH:17][C:16]=3[N:13]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 509940363-Nitro-2'-trifluoromethyl-biphenyl-4-ylamineHCID 67528472HCID 67528472, compound

Product 1

HCID 178422995(E)-2-[2-(4-Methyl-tetrahydro-pyran-4-yl)-vinyl]-5-(2-trifluoromethyl-phenyl)-1H-benzimidazole

Procedure

(E)-2-[2-(4-Methyl-tetrahydro-pyran-4-yl)-vinyl]-5-(2-trifluoromethyl-phenyl)-1H-benzimidazole was prepared from the acid chloride of 3-(4-methyl-tetrahydro-pyran-4-yl)-acrylic acid (prepared as in STEP B above) and 3-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (prepared as described in Example 3, STEP A) following the procedure as described in Example 8, STEP C.

Sources & evidence

ORD record
ord-13fff5b1129d4b9c8a8ac71a4e6bc568
Source dataset
uspto-grants-2012_07
Patent number
US08217060B2

Reaction notes

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