Hydrochloric Acid → HCID 178478958, compound

HRID 1512185Notes

Reaction equation

HRID 1512185 reaction equation
[CH:1]1([CH:7]=[CH:8][C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:24]([F:27])([F:26])[F:25])=[CH:17][C:11]=3[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:28]>C(OCC)C>[ClH:28].[CH:1]1([CH:7]=[CH:8][C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:24]([F:26])([F:27])[F:25])=[CH:17][C:11]=3[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178506128HCID 178506128, compound

Product 1

HCID 178478958HCID 178478958, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 2-(2-cyclohexyl-vinyl)-5-(2-trifluoromethyl-phenyl)-1H-benzoimidazole (0.25 g, 0.66 mmol) in ethyl ether (5 ml) was treated with 2M HCl in ethyl ether (0.36 ml, 0.73 mmol). After five minutes the resulting solution was concentrated and dried in vacuo to yield the title compound.

Workup

  1. concentrationAfter five minutes the resulting solution was concentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-8fc7942d1cd245bf8afd9d35ddca0427
Source dataset
uspto-grants-2012_07
Patent number
US08217060B2

Reaction notes

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