反应详情

温度

20 °C

Cyclopropanecarboxylic acid (4-nitro-pyridin-2-yl)-amide (200 mg, 0.965 mmol), 6-hydroxy-isoquinoline-1-carboxylic acid (183 mg, 0.965 mmol), and potassium carbonate (267 mg, 1.93 mmol) are stirred in dimethylsulphoxide (10 mL) at 90° C. for 24 h. After cooling to 20° C., the dimethylsulphoxide is partially evaporated under reduced pressure, water is added, the solution is carefully acidified with trifluoroacetic acid and the resulting solution is purified using a MPLC reverse phase chromatography (Merck LiChroprep® RP-18, acetonitrile/water 0.1% trifluoroacetic acid) to afford the title compound as a solid. M-H, 348.1; HPLC tR: 3.29 min.

1. customthe dimethylsulphoxide is partially evaporated under reduced pressure, water
2. additionis added
3. customthe resulting solution is purified