反应详情

温度

60 °C

146 mg (0.91 mmol) of 1-(3-chloropropyl)pyrrolidin-2-one [CAS Reg. No. 91152-30-6] and 295 mg (0.91 mmol) of anhydrous cesium carbonate are added to a solution of 215 mg (0.45 mmol) of methyl 4-[(4E)-5-(5-fluoro-2-hydroxyphenyl)-3-{2-[4-(methoxycarbonyl)phenyl]ethyl}pent-4-en-1-yl]benzoate in 5 ml of dry DMF, and the mixture is then stirred at 60° C. for 12 h. The mixture is then filtered, and the filtrate is evaporated to dryness. The residue is purified by preparative HPLC. This gives 165 mg (purity 93%, 0.25 mmol, 56% of theory) of a colorless oil.

1. filtrationThe mixture is then filtered
2. customthe filtrate is evaporated to dryness
3. customThe residue is purified by preparative HPLC