反应详情

A solution of 16.7 mg (0.19 mmol) of 2-oxazolidinone [CAS Reg. No. 497-25-6] is initially charged in 1.0 ml of dry DMF, and 7.9 mg (0.196 mmol) of sodium hydride (60% in paraffin oil) are added. The mixture is stirred at room temperature for 45 min. The reaction solution is then cooled to 0° C. and a solution of 30 mg (0.055 mmol) of methyl 4-{(4E)-5-{2-[(5-chloropentyl)oxy]phenyl}-3-[4-(methoxycarbonyl)benzyl]pent-4-en-1-yl}benzoate (racemate; Example 32A) in 0.5 ml of dry DMF is added. The mixture is stirred at room temperature for 1.5 h. The reaction solution is then carefully poured into 5 ml of ice-cold 10% strength ammonium chloride solution. The mixture is extracted twice with dichloromethane. The combined organic phases are dried over sodium sulfate, filtered and concentrated. This gives 25 mg (0.042 mmol, 76% of theory) of a colorless oil which is reacted without further purification.

1. temperatureThe reaction solution is then cooled to 0° C.
2. stirringThe mixture is stirred at room temperature for 1.5 h
3. extractionThe mixture is extracted twice with dichloromethane
4. dry with materialThe combined organic phases are dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customThis gives 25 mg (0.042 mmol, 76% of theory) of a colorless oil which is reacted without further purification