2-Chloro-3-pyridinol → 2-(2-Chloro-pyridin-3-yloxy)-5-fluoro-benzonitrile

HRID 1512260Notes

Reaction equation

HRID 1512260 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[C:4]#[N:5].[Cl:11][C:12]1[C:17]([OH:18])=[CH:16][CH:15]=[CH:14][N:13]=1>>[Cl:11][C:12]1[C:17]([O:18][C:2]2[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=2[C:4]#[N:5])=[CH:16][CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 811362-Chloro-3-pyridinolHCID 1235582,5-Difluorobenzonitrile

Product 1

HCID 860823032-(2-Chloro-pyridin-3-yloxy)-5-fluoro-benzonitrile

Procedure

2,5-Difluoro-benzonitrile was reacted with 2-chloropyridin-3-ol according to the method of Example 78A to provide the title compound. MS (DCI/NH3) m/z 249 (M)+, 251 (M+2)+.

Sources & evidence

ORD record
ord-5c4b5c3f0854489385e4eab4dcf49bd9
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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