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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512260Generated: October 27, 2026

2-Chloro-3-pyridinol → 2-(2-Chloro-pyridin-3-yloxy)-5-fluoro-benzonitrile

https://huagongshe.com/reaction/1512260

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-3-pyridinolHCID 81136—
Reactant2,5-DifluorobenzonitrileHCID 123558—
Product2-(2-Chloro-pyridin-3-yloxy)-5-fluoro-benzonitrileHCID 86082303—

Reaction Steps

2,5-Difluoro-benzonitrile was reacted with 2-chloropyridin-3-ol according to the method of Example 78A to provide the title compound. MS (DCI/NH3) m/z 249 (M)+, 251 (M+2)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217067B2
Source datasetuspto-grants-2012_07
ORD IDord-5c4b5c3f0854489385e4eab4dcf49bd9
Source noteuspto-grants-2012_07