1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloxime → 1'-Methyl-2,3-dihydrospiro[indene-1,4'-piperidin]-3-amine

HRID 1512302Notes

Reaction equation

HRID 1512302 reaction equation
CO[N:3]=[C:4]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]2([CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2)[CH2:5]1>[Ni]>[CH3:12][N:9]1[CH2:8][CH2:7][C:6]2([C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:4]([NH2:3])[CH2:5]2)[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 860822791'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloxime

Product 1

HCID 685844981'-Methyl-2,3-dihydrospiro[indene-1,4'-piperidin]-3-amine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The product of Example 138C and Raney/nickel were processed according to the method of Example 131C to provide the product. MS (ESI+) m/z 217 (M+H)+.

Workup

  1. customto provide the product

Sources & evidence

ORD record
ord-a168d0f5b0c64a6e8af43c478737d639
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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