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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512302Generated: November 4, 2026

1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloxime → 1'-Methyl-2,3-dihydrospiro[indene-1,4'-piperidin]-3-amine

https://huagongshe.com/reaction/1512302

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloximeHCID 86082279—
CatalystNickelHCID 935—
Product1'-Methyl-2,3-dihydrospiro[indene-1,4'-piperidin]-3-amineHCID 68584498—

Reaction Steps

The product of Example 138C and Raney/nickel were processed according to the method of Example 131C to provide the product. MS (ESI+) m/z 217 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217067B2
Source datasetuspto-grants-2012_07
ORD IDord-a168d0f5b0c64a6e8af43c478737d639
Source noteuspto-grants-2012_07