Pyrrolidine → HCID 86082298, compound

HRID 1512337Notes

Reaction equation

HRID 1512337 reaction equation
[Cl:1][C:2]1[C:7](F)=[C:6]([C:9]#[N:10])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>>[Cl:1][C:2]1[C:7]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:6]([CH:5]=[CH:4][N:3]=1)[C:9]#[N:10]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 717573152-chloro-3-fluoro-4-cyanopyridine

Product 1

HCID 86082298HCID 86082298, compoundYield 94%

Procedure

Prepared in 94% yield from 2-chloro-4-cyano-3-fluoropyridine and pyrrolidine according to the procedure described for Example 178A. MS (ESI+) m/z 207.9 (M+H)+; 1H NMR (DMSO-d6) δ 1.91-1.95 (m, 4H), 3.62-3.67 (m, 4H), 7.63 (d, J=4.7 Hz, 1H), 7.98 (d, J=4.7 HZ, 1H).

Sources & evidence

ORD record
ord-cd73ea4aa02b4fa98299b7dfe47b5d87
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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