Azetidine hydrochloride → HCID 68583271, compound

HRID 1512341Notes

Reaction equation

HRID 1512341 reaction equation
Cl[C:2]1[N:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[C:4]#[N:5].Cl.[NH:12]1[CH2:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[N:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=2[C:4]#[N:5])[CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 12308726Azetidine hydrochlorideHCID 231108512-Chloro-5-fluoropyridine-3-carbonitrile

Product 1

HCID 68583271HCID 68583271, compoundYield 78%

Procedure

Prepared in 78% yield from the product of Example 169A and azetidine hydrochloride according to the procedure described for Example 178A. MS (ESI+) m/z 177.8 (M+H)+; 1H NMR (DMSO-d6) δ 2.28-2.38 (m, 2H), 4.17-4.22 (m, 4H), 8.07 (dd, J=8.3, 2.9 Hz, 1H), 8.66 (dd, J=8.1, 3.0 Hz, 1H).

Sources & evidence

ORD record
ord-7a5ef52d9f254bf095acaa2d9eb1a2d9
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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