HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(Trifluoromethyl)benzyl mercaptan | HCID 141236 | — |
| Reactant | HCID 86652406 | HCID 86652406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanone | HCID 66577341 | — |
Reaction Steps
2-Bromo-1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanone and triethylamine were combined in CH2Cl2. (3-trifluoromethyl-phenyl)-methanethiol was added, and the reaction was stirred at room temperature for at least 1 hour. After workup, the crude material was purified by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217066B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-b209d36e95c44ec898c3917f0fa4e76d |
| Source note | uspto-grants-2012_07 |