Triethylamine → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanone

HRID 1512678Notes

Reaction equation

HRID 1512678 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([CH3:17])=[N:7][O:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=1)=[O:4].C(N(CC)CC)C.[F:25][C:26]([F:36])([F:35])[C:27]1[CH:28]=[C:29]([CH2:33][SH:34])[CH:30]=[CH:31][CH:32]=1>C(Cl)Cl>[Br:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]2[O:8][N:7]=[C:6]([CH3:17])[C:5]=2[C:3](=[O:4])[CH2:2][S:34][CH2:33][C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([C:26]([F:25])([F:35])[F:36])[CH:28]=2)=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1412363-(Trifluoromethyl)benzyl mercaptanHCID 86652406HCID 86652406, compound

Product 1

HCID 665773411-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Bromo-1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanone and triethylamine were combined in CH2Cl2. (3-trifluoromethyl-phenyl)-methanethiol was added, and the reaction was stirred at room temperature for at least 1 hour. After workup, the crude material was purified by silica gel chromatography.

Workup

  1. customAfter workup, the crude material was purified by silica gel chromatography

Sources & evidence

ORD record
ord-b209d36e95c44ec898c3917f0fa4e76d
Source dataset
uspto-grants-2012_07
Patent number
US08217066B2

Reaction notes

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