Chlorosuccinimide → 2-Amino-5-chloro-3-nitrobenzamide

HRID 1512704ノート

反応式

HRID 1512704 の反応式
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:14]N1C(=O)CCC1=O>C(#N)C>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 107974762-Amino-3-nitrobenzamide

生成物 1

HCID 251933202-Amino-5-chloro-3-nitrobenzamide収率 84%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Amino-3-nitrobenzamide (4.0 g) in warm anhydrous acetonitrile (1.25 L) was treated with N-chlorosuccinimide (3.1 g) at 60° C. under nitrogen for 20 hours. The mixture was allowed to cool to room temperature and filtered. The filter cake was washed with acetonitrile and dried to provide the title compound (3.98 g, 84%). MS (DCI/NH3) m/z 216 (M+H)+.

後処理

  1. filtrationfiltered
  2. washThe filter cake was washed with acetonitrile
  3. customdried

出典と根拠

ORDレコード
ord-9504092d5b6c4e348f26e01c38e22ef9
出典データセット
uspto-grants-2012_07
特許番号
US08217070B2

反応ノート

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