HCID 44549262, compound → HCID 53404692, compound

HRID 1512980Notes

Reaction equation

HRID 1512980 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1>C(O)C.[C].[Pd]>[NH2:8][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:5][CH:6]=1

Participants

4

Reactant 1

HCID 44549262HCID 44549262, compound

Product 1

HCID 53404692HCID 53404692, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 4-methyl-5-nitropyridine-2-carboxylate (3.23 g) and 10% palladium-carbon powder (0.65 g) in ethanol (50 mL) was stirred at room temperature under a hydrogen atmosphere overnight. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (2.74 g).

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-affccc2327f74309bef80e98dd2f71e6
Source dataset
uspto-grants-2012_07
Patent number
US08217069B2

Reaction notes

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