Nitric Acid → HCID 178433493, compound

HRID 1513016Notes

Reaction equation

HRID 1513016 reaction equation
[N+:1]([O-:4])(O)=[O:2].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([CH3:13])[N:7]=1>>[OH:5][C:6]1[C:11]([N+:1]([O-:4])=[O:2])=[C:10]([OH:12])[N:9]=[C:8]([CH3:13])[N:7]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 178418389HCID 178418389, compound

Product 1

HCID 178433493HCID 178433493, compound

Procedure

To fuming nitric acid (50 mL) was added 4,6-dihydroxy-2-methylpyrimidine (25 g) slowly under ice-cooling, and the mixture was stirred at the same temperature for 15 minutes. To the reaction mixture was added ice water (500 mL), and the resulting mixture was stirred at room temperature until the ice melted. The precipitated crystals were collected by filtration. The collected crystals were washed with water, and dried under reduced pressure to give the title compound (26.6 g).

Workup

  1. temperaturecooling
  2. filtrationThe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-97c60ed1085249f5b8cf5c906295fd78
Source dataset
uspto-grants-2012_07
Patent number
US08217069B2

Reaction notes

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