HCID 68515720, compound → HCID 59309806, compound

HRID 1513096Notes

Reaction equation

HRID 1513096 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH2:11][C:12]2[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:13]=2[F:20])=[CH:4][C:3]=1[N:21]1[C:29](=[O:30])[NH:28][C:27]2[C:22]1=[N:23][C:24]([CH2:33][Cl:34])=[N:25][C:26]=2[O:31][CH3:32].[N:35]([CH2:38][C:39]1[N:47]=[C:46]2[C:42]([NH:43][C:44](=[O:68])[N:45]2[C:48]2[CH:53]=[C:52]([O:54][CH2:55][C:56]3[C:61]([O:62][CH3:63])=[CH:60][CH:59]=[CH:58][C:57]=3[F:64])[C:51]([O:65][CH3:66])=[CH:50][C:49]=2[Cl:67])=[C:41]([O:69][CH3:70])[N:40]=1)=[N+:36]=[N-:37]>[Pt].[C].O1CCCC1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH2:11][C:12]2[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:13]=2[F:20])=[CH:4][C:3]=1[N:21]1[C:29](=[O:30])[NH:28][C:27]2[C:22]1=[N:23][C:24]([CH2:33][Cl:34])=[N:25][C:26]=2[O:31][CH3:32].[N:35]([CH2:38][C:39]1[N:47]=[C:46]2[C:42]([NH:43][C:44](=[O:68])[N:45]2[C:48]2[CH:53]=[C:52]([O:54][CH2:55][C:56]3[C:61]([O:62][CH3:63])=[CH:60][CH:59]=[CH:58][C:57]=3[F:64])[C:51]([O:65][CH3:66])=[CH:50][C:49]=2[Cl:67])=[C:41]([O:69][CH3:70])[N:40]=1)=[N+:36]=[N-:37].[NH2:35][CH2:33][C:24]1[N:23]=[C:22]2[C:27]([NH:28][C:29](=[O:30])[N:21]2[C:3]2[CH:4]=[C:5]([O:10][CH2:11][C:12]3[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:13]=3[F:20])[C:6]([O:8][CH3:9])=[CH:7][C:2]=2[Cl:1])=[C:26]([O:31][CH3:32])[N:25]=1

Participants

7

Reactant 2

HCID 68515720HCID 68515720, compoundHCID 86641291HCID 86641291, compound

Product 3

HCID 59309806HCID 59309806, compoundHCID 68515720HCID 68515720, compoundHCID 86641291HCID 86641291, compound

Reagents, catalysts & solvents 2

HCID 178503042HCID 178503042, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

9-[2-Chloro-5-(2-fluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2-chloromethyl-6-methoxy-7,9-dihydro-8H-purin-8-one was prepared in a similar manner to that described in Example 410 using the corresponding starting materials. 2-Azidomethyl-9-[2-chloro-5-(2-fluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-6-methoxy-7,9-dihydro-8H-purin-8-one was prepared in a similar manner to that described in Example 413 using 9-[2-chloro-5-(2-fluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2-chloromethyl-6-methoxy-7,9-dihydro-8H-purin-8-one instead of 9-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2-chloromethyl-6-methoxy-7,9-dihydro-8H-purin-8-one. To 2-azidomethyl-9-[2-chloro-5-(2-fluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-6-methoxy-7,9-dihydro-8H-purin-8-one (0.1 g) were added tetrahydrofuran (10 mL) and 10% platinum-carbon powder (50 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere for 4 hours. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (94 mg).

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-92e4fba2a8be403f82de2f1b0c8e5267
Source dataset
uspto-grants-2012_07
Patent number
US08217069B2

Reaction notes

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