Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione
Reaction equation
[N:1]1[NH:2][C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:2]1[C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=[N:1]1)(=[O:11])[CH3:10]Participants
3
Procedure
1,2,4-Triazine-3,5(2H,4H)-dione, commercially available from Alfa Aesar (800 mg, 7.07 mmol) was suspended in acetic anhydride (4 ml, 42.4 mmol) and the mixture was refluxed for 2 h. The reaction mixture was then cooled to room temperature and dried under vacuum. The crude product was repeatedly treated with toluene and concentrated under vacuum to give, as a light brown solid, the title compound (1.05 g, 96%) that was used in the next step without purification.
Workup
- temperaturethe mixture was refluxed for 2 h
- customdried under vacuum
- additionThe crude product was repeatedly treated with toluene
- concentrationconcentrated under vacuum
- customto give, as a light brown solid
- customthe title compound (1.05 g, 96%) that was used in the next step without purification
Sources & evidence
- ORD record
- ord-2f3b7bdfec754fffaff09268ae3d5cae
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08217168B2
Reaction notes
Loading…