Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

Participants

Reaction Steps

1,2,4-Triazine-3,5(2H,4H)-dione, commercially available from Alfa Aesar (800 mg, 7.07 mmol) was suspended in acetic anhydride (4 ml, 42.4 mmol) and the mixture was refluxed for 2 h. The reaction mixture was then cooled to room temperature and dried under vacuum. The crude product was repeatedly treated with toluene and concentrated under vacuum to give, as a light brown solid, the title compound (1.05 g, 96%) that was used in the next step without purification.

Provenance & Evidence