Acetic Anhydride → HCID 59496098, compound

HRID 1513340Notes

Reaction equation

HRID 1513340 reaction equation
[C:1]1([C:7]2[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([N:11]1[C:10](=[O:13])[NH:9][C:8](=[O:14])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:12]1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 2533636-phenyl-1,2,4-triazine-3,5(2h,4h)-dione

Product 1

HCID 59496098HCID 59496098, compoundYield 64.3%

Procedure

6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione (prepared as described in BMCL, 2005, 43, 4363, 56 mg, 0.296 mmol) was heated in acetic anhydride (2 ml, 21.20 mmol) at 110° C. for 2 h, than was left at r.t. overnight. Solvent was evaporated under reduced pressure, obtaining 44 mg of title compound (64.3% yield).

Workup

  1. customSolvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-13c36f8a9fbf47089780f53016a0f194
Source dataset
uspto-grants-2012_07
Patent number
US08217168B2

Reaction notes

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