反应详情

6-(2-fluoro-3-pyridinyl)-2-(3-{1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (E11, 14 mg, 0.029 mmol) was dissolved in 2 mL of DCM and treated with HCl 1.25M in MeOH (2.2 eq) to form 6-(2-fluoro-3-pyridinyl)-2-(3-{1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione dihydrochloride salt (Enantiomer 2) (E12, 15.7 mg, 0.028 mmol).