Hydrochloric Acid → HCID 68431841, compound

HRID 1513354Notes

Reaction equation

HRID 1513354 reaction equation
[C:1]1([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][CH:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:34]>C(OCC)C>[ClH:34].[C:1]1([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:31])[F:29])=[CH:26][CH:27]=5)([CH2:19]4)[CH2:17]3)[N:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68431842HCID 68431842, compound

Product 1

HCID 68431841HCID 68431841, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

6-phenyl-2-(3-{(1S)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (9 mg 0.019 mmol) was diluted in diethyl ether (1 ml) and hydrochloric acid 1M in Et2O (0.022 ml, 0.022 mmol) under nitrogen atmosphere. Solvent was removed and the residue triturated in Et2O (2×1 mL), obtaining 3.2 mg of title compound as a white solid (27% yield).

Workup

  1. customSolvent was removed
  2. customthe residue triturated in Et2O (2×1 mL)

Sources & evidence

ORD record
ord-01c0ca8a0a4445239d043c19644355b8
Source dataset
uspto-grants-2012_07
Patent number
US08217168B2

Reaction notes

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