反应详情

6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (19.7 mg 0.041 mmol, prepared following an analoguos procedure to that described for Ex9) was diluted in diethyl ether (1 ml) and hydrochloric acid 1M in Et2O (0.045 ml, 0.045 mmol) under nitrogen atmosphere. Solvent was removed and the residue triturated in Et2O (2×1 mL), obtaining 21.8 mg of title compound as a white solid.

1. customSolvent was removed
2. customthe residue triturated in Et2O (2×1 mL)