Hydrochloric Acid → 1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea hydrochloride

HRID 1513430Notes

Reaction equation

HRID 1513430 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][C:32]([C:35]([N:37]5[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]5)=[O:36])=[CH:31][CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[N:8]=2)[CH2:3][CH2:2]1.CO.[ClH:46]>O1CCOCC1>[ClH:46].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:30]=[CH:31][C:32]([C:35]([N:37]5[CH2:38][CH2:39][N:40]([CH3:43])[CH2:41][CH2:42]5)=[O:36])=[CH:33][CH:34]=4)=[O:27])=[CH:21][CH:20]=3)[N:8]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 44516309HCID 44516309, compound

Product 1

HCID 453792241-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea (70 mg, 0.119 mmol) and MeOH (1 mL) was added 4N HCl in Dioxane (1 mL), stirred for 3 hrs. The solid was filtered and washed with ether to give the product as a white solid (74 mg, yield=100%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with ether

Sources & evidence

ORD record
ord-57c91b1df8164d42afbd119fb3f9000b
Source dataset
uspto-grants-2012_07
Patent number
US08217036B2

Reaction notes

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