Hydrochloric Acid → HCID 45379226, compound

HRID 1513433Notes

Reaction equation

HRID 1513433 reaction equation
[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]([CH3:42])[C:6](=[O:41])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[N:28]=[C:27]([N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)[N:26]=[C:25]([N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)[N:24]=3)=[CH:19][CH:18]=2)=[O:15])=[CH:9][CH:8]=1.CO.[ClH:46]>O1CCOCC1>[ClH:46].[CH3:1][N:2]([CH3:43])[CH2:3][CH2:4][N:5]([CH3:42])[C:6](=[O:41])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]3[N:28]=[C:27]([N:29]4[CH2:30][CH2:31][O:32][CH2:33][CH2:34]4)[N:26]=[C:25]([N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)[N:24]=3)=[CH:21][CH:22]=2)=[O:15])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 44516311N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide

Product 1

HCID 45379226HCID 45379226, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To the N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide (55 mg, 0.127 mmol) and MeOH (1 mL) was added 4N HCl in Dioxane (1 mL) and stirred for 3 hrs. The solid was filtered and washed with ether to give the product as a white solid (70 mg, yield=88%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with ether

Sources & evidence

ORD record
ord-f187e1ad094f4e11b10df12aa75744fc
Source dataset
uspto-grants-2012_07
Patent number
US08217036B2

Reaction notes

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