Hydrochloric Acid → 2,6,8-Decatrienoic acid
Reaction equation
C[O:2][C:3](=[O:13])[CH:4]=[CH:5][CH2:6][CH2:7][CH:8]=[CH:9][CH:10]=[CH:11][CH3:12].[OH-].[K+].Cl>>[C:3]([OH:13])(=[O:2])[CH:4]=[CH:5][CH2:6][CH2:7][CH:8]=[CH:9][CH:10]=[CH:11][CH3:12]Participants
4
Conditions
- Temperature
- 70 °C
Procedure
In an atmosphere of nitrogen, 2,6,8-decatrienoic acid methyl ester (6); 19.1 g {GC; 93.9%, pure amount; 17.9 g (0.0995 mol)} and 5 mol/l of potassium hydroxide aqueous solution (60 ml, 0.30 mol) were added to a 200 ml capacity flask, followed by stirring at 70° C. for 2 hours. After completion of the reaction, the reaction was stopped with 5 mol/l of hydrochloric acid (63 ml, 0.315 mol), and then extraction with toluene (32 ml) was carried out to obtain a toluene solution of 2,6,8-decatrienoic acid (7).
Workup
- customAfter completion of the reaction
- extractionextraction with toluene (32 ml)
Sources & evidence
- ORD record
- ord-58a13f48140e47ffa6289fcdeaf312d1
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08217192B2
Reaction notes
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