Hydrogen chloride-ethyl acetate → HCID 66892889, compound

HRID 1513579Notes

Reaction equation

HRID 1513579 reaction equation
[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([N:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]1[CH2:34][NH:35]C(=O)OC(C)(C)C)=[O:27].C(OC(=O)C)C.[ClH:49]>C(OCC)(=O)C>[ClH:49].[NH2:35][CH2:34][CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][N:28]1[C:26]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:8](=[O:25])[C:7]=2[C:3]=1[O:2][CH3:1])=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86634218HCID 86634218, compound

Product 1

HCID 66892889HCID 66892889, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the obtained tert-butyl [(1-{[3-methoxy-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydrothieno[3,2-c]quinolin-2-yl]carbonyl}piperidin-2-yl)methyl]carbamate (150 mg) and 4N hydrogen chloride ethyl acetate solution (8 mL) in ethyl acetate (15 mL) was stirred at room temperature for 18 hr. The obtained precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (133 mg, 67%) as a white powder.

Workup

  1. filtrationThe obtained precipitate was collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-da80518a61a843399b148c67d3a4aeb5
Source dataset
uspto-grants-2012_07
Patent number
US08217176B2

Reaction notes

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